Skrining Senyawa dari Tanaman Rhodomyrtus tomentosa (Aiton) Hassk terhadap SARS-CoV-2 ORF3a

The ORF3a protein from SARS-CoV has functions in terms of ion channel activity, modulates the trafficking properties spike (S) protein, increases fibrinogen expression pulmonary epithelial cells, and induces apoptosis. So that research is needed to overcome experiment. method this uses computational screening with autodok4 software. results study resulted free binding energy between Hassk Rhodomyrtus tomentosa (Aiton) compounds, namely: α-tocopherol-quinone (-5.86); blumeatin (-4.98); methyl cinnamate (-4.44); myricetin (-4.49); naringenin (-4.93); quercetin (-4,9); rhodomyrtone (-6); rhodomyrtosone B (-7.11); C (-6.77); tetrahydroxyflavanone (-4.91); α-tocopherol A (-6.72); verimol K (-4.89); watsonianone (-7.55). Based on data obtained, ligand most potential due stability bond A.